The 63-year-old singer, who had hits including Hot Stuff, Love to Love You, Baby and I Feel Love, died in Florida on Thursday morning.
She had largely kept her battle with lung cancer out of the public eye. But the website TMZ reported that the singer had told friends she believed her illness was the result of inhaling toxic dust from the collapsed Twin Towers.
On Thursday night tributes were paid to the singer, considered by many to be the voice of the 1970s.
A statement released on behalf of her family — husband Bruce Sudano, their daughters Brooklyn and Amanda, her daughter, Mimi from a previous marriage and four grandchildren — read: “Early this morning, surrounded by family, we lost Donna Summer Sudano, a woman of many gifts, the greatest being her faith.
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“Words truly can’t express how much we appreciate your prayers and love for our family at this sensitive time.”
She had spoken at length about September 11.
In a 2008 interview with The Daily Telegraph, she said she had a premonition about the attacks a month beforehand. Afterwards she said she suffered from severe depression and could not leave her Manhattan flat.
“I didn’t want to talk to anybody. I had to keep the blinds down and stay in my bedroom,” she said.
Music industry heavyweights spoke of their respect for Summer.
Sir Elton John said: “I’m so sad. This woman was the queen of disco and so much more.
"That she has never been inducted into the Rock 'n’ Roll Hall of Fame is a total disgrace, especially when I see the second-rate talent that has been inducted. Her records sound as good today as they ever did.”
Quincy Jones, who produced albums for Summer, wrote on Twitter: “Rest in peace dear Donna Summer. Your voice was the heartbeat and soundtrack of a decade.”
Gloria Estefan wrote: “Few singers have impacted music and the world like Donna Summer! It’s the end of an era.”
Kylie Minogue said that Summer was “one of my earliest musical inspirations”, while the musician Moby said: “Words can’t express the impact and influence she had on music.”