Online: | |
Visits: | |
Stories: |
by Tom Bunzel
Collective Evolution
Have you thought deeply about the latest discovery in genetics? DUF1220 – “DUF” stands for a (protein) domain of unknown function –presumably “junk DNA.” But this one seems to be what distinguishes us as “human” and may correspond to greater brain functionality.
In fact, we possess more than twice the amount of replications (copies) of this protein as a result of the instructions (code) of our genome than our nearest genetic relative –the chimp. It seems to be clearly related to the growth of certain parts of the brain –and presumably to more sophisticated neural networks.
According to Wikipedia:
“DUF1220 is a protein domain of unknown function that shows a striking human lineage-specific (HLS) increase in copy number and may be important to human brain evolution.[1] The copy number of DUF1220 domains increases generally as a function of a species evolutionary proximity to humans. DUF1220 copy number is highest in human (over 270, with some person-to-person variations).[2] and shows the largest HLS increase in copy number (an additional 160 copies) of any protein coding region in the human genome. DUF1220 copy number is reduced in African great apes (estimated 125 copies in chimpanzees), further reduced in orangutan (92) and Old World monkeys (35), single- or low-copy in non-primate mammals and absent in non-mammals.”