High Doses of Cocaine Can Cause the Braine to Eat Itself
This party may come at an irrecoverable cost. (Valerie Everett / (CC BY-SA 2.0))
Is it time to revise your weekend plans?
Mice given high doses of cocaine exhibited a condition known as autophagy, in which brain cells digest and excrete essential parts, rather than just waste.
Associated Press reports via The Guardian:
Dr Prasun Guha, from Johns Hopkins University School of Medicine in the US, who led the research published in the journal Proceedings of the National Academy of Sciences, said: “A cell is like a household that is constantly generating trash. Autophagy is the housekeeper that takes out the trash – it’s usually a good thing. But cocaine makes the housekeeper throw away really important things, like mitochondria, which produce energy for the cell.”
The scientists carried out postmortems that showed clear signs of autophagy-induced cell death in the brains of mice given high doses of cocaine. They also found evidence of autophagy in the brain cells of mice whose mothers received the drug while pregnant.
The scientists showed that an experimental drug called CGP3466B was able to protect mouse nerve cells from cocaine death due to autophagy. Since the drug has already been tested in clinical trials to treat Parkinson’s and motor neurone disease, it is known to be safe in humans. But much more research is needed to find out whether the drug can prevent the harmful effects of cocaine in people, said the team.
Continue reading here.
—Posted by Alexander Reed Kelly.
Related Entries
- January 13, 2016 Outrage in Oregon
- December 31, 2015 A Most Unhappy New Year at Guantanamo
Source: http://www.truthdig.com/eartotheground/item/high_doses_of_cocaine_can_cause_the_braine_to_eat_itself_20160120/
It probably has eaten yours already cos brain has no e in it!