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A new report by the European Academies' Science Advisory Council on genome editing gives advice to European policy-makers on groundbreaking research involving genome editing and plants, animals, microbes and patients. In this report, “Genome Editing: Scientific opportunities, public interests, and policy options in the EU”, EASAC emphasises that policy-makers must ensure that the regulation of applications is evidence-based, takes into account likely benefits as well as hypothetical risks, and is proportionate and sufficiently flexible to cope with future advances in the science.