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Magic Bullets: 40 Plant-Based Compounds Can Turn On Genes That Slow Or Stop The Spread Of Cancer

Monday, August 27, 2012 12:27
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More than 40 plant-based compounds can turn on genes that slow or stop the spread of cancer, according to a first-of-its-kind study by a Washington State University researcher.

Gary Meadows, WSU professor and associate dean for graduate education and scholarship in the College of Pharmacy, says he is encouraged by his findings because the spread of cancer is most often what makes the disease fatal. Moreover, says Meadows, diet, nutrients and plant-based chemicals appear to be opening many avenues of attack.

 
Making pomegranate juice
File:Makingpomegranatejuice.jpg
Credit: Wikipedia

“We’re always looking for a magic bullet,” he says. “Well, there are lots of magic bullets out there in what we eat and associated with our lifestyle. We just need to take advantage of those. And they can work together.”

Meadows started the study, recently published online in the journal Cancer and Metastasis Reviews, with some simple logic: Most research focuses on the prevention of cancer or the treatment of the original cancer tumor, but it’s usually the cancer’s spread to nearby organs that kills you. So rather than attack the tumor, said Meadows, let’s control its spread, or metastasis.

He focused in particular on genes that suppress metastasis. As search engine terms go, it took him down many a wormhole in the PubMed research database, as the concept of nutrients and metastasis suppressor genes is rarely identified by journals. It’s even an afterthought of some of the researchers who find the genes.

“People for the most part did not set out in their research goals to study metastasis suppressor genes,” says Meadows. “It was just a gene that was among many other genes that they had looked at in their study.”

But Meadows took the studies and looked to see when metastasis suppressor genes were on or off, even if original authors didn’t make the connection. In the end, he documented dozens of substances affecting the metastasis suppressor genes of numerous cancers.

He saw substances like amino acids, vitamin D, ethanol, ginseng extract, the tomato carotenoid lycopene, the turmeric component curcumin, pomegranate juice, fish oil and others affecting gene expression in breast, colorectal, prostate, skin, lung and other cancers.

Typically, the substances acted epigenetically, which is to say they turned metastasis suppressor genes on or off.

“So these epigenetic mechanisms are influenced by what you eat,” he says. “That may also be related to how the metastasis suppressor genes are being regulated. That’s a very new area of research that has largely not been very well explored in terms of diet and nutrition.” Meadows says his study reinforces two concepts.

For one, he has a greater appreciation of the role of natural compounds in helping our bodies slow or stop the spread of cancer. The number of studies connecting nutrients and metastasis suppressor genes by accident suggests a need for more deliberate research into the genes.

“And many of these effects have not been followed up on,” he says. “There’s likely to be more compounds out there, more constituents, that people haven’t even evaluated yet.”

Meadows also sees these studies playing an important role in the shift from preventing cancer to living with it and keeping it from spreading.

“We’ve kind of focused on the cancer for a long time,” he says. “More recently we’ve started to focus on the cancer in its environment. And the environment, your whole body as an environment, is really important in whether or not that cancer will spread.”
 

Contacts and sources:
Gary Meadows
Washington State University

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  • One wonders where these clever people have been for the last few years. I’m not a scientist, but I’ve known about the fact that vitamin D reduces BC metastasis by 800% for at least two years. And that the various pink-ribbon charities are noticeably quiet when it comes to telling women about this fact. The awful realisation begins to bite that they do not want to cure cancer, it’s far too lucrative an industry. Which this most recent neophyte will learn as soon as he begins to ask for funding to continue his studies. This is all anyone wants to do, not to help people, but to do “more studies”. It’s quite sickening.
    Incidentally, here’s an insider tip for him. Approach the MD Anderson Cancer Centre in Texas. They have a wealth of information about many of these substances, eg curcumin, which hje can brush up his knowledge base on.

  • The problem is pharmacies never use these substances as Natural Intelligence intended (no profits in that). They extract this or that thinking they are so clever, but the Whole Plant Medicine is always the best – by extracting so-called active ingredients the medicine becomes unbalanced, leading to unwanted side-effects. Also I don’t believe for a second the pharmaceutical companies really want to find a cure (even if they did it would be quashed by their superiors as it would threaten sickness industry profits). They want ‘magic bullets’ that they can patent, press into a pill, and charge us for it when Nature intended it to be freely available for everybody to be healthy. If you don’t take care of yourself, your internal eco-systems and eat well, expect to get sick eventually. That’s simple science for you.

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