The role of histamine on cognition
Home of Kyle J. Norton for The Better of Living & Living Health Histamine, found within granules of basophils and mast cells (>90% of body stores) is a biogenic amine and an organic nitrogen compound that occurs to various degrees in many foods such as cherries to about 0.17-13.46 ng/g, bananas and grapes, rice and cereals, herbs, olive oil, wine, beer, etc.. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity(a). the hormone, as a neurotransmitter is involved in regulating physiological function in the gut and immune response to foreign pathogens.
The role of histamine on cognition
The specific participation of histamine in cognitive functions followed a slow and unclear pathway because the many different experimental learning models, pharmacologic approaches, systemic and localized applications of the histamine active compounds into the brain used by researchers showed facilitating or inhibitory effects on learning, generating an active issue that has extended up to present time. The specific histamine receptors and the compartmentalizing proprieties of the brain that might explain the apparent inconsistent effects of the imidazolamine in learning. In addition, a hypothetical physiologic role for histamine in memory is proposed under the standard theories of learning in experimental animals and humans.according to the study of Dr. Edgardo O. Alvarez at the Universidad Nacional de Cuyo, Laboratorio de Neuropsicofarmacología Experimenta(9).
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Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/17490952
(9) http://www.sciencedirect.com/science/article/pii/S016643280800675X
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2012-10-30 21:22:16
Source: http://medicaladvisorjournals.blogspot.com/2012/10/the-role-of-histamine-on-cognition.html
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