The role of histamine H1 and H4 receptors in allergic inflammation
Home of Kyle J. Norton for The Better of Living & Living Health (Hormone)Histamine, found within granules of basophils and mast cells (>90% of body stores) is a biogenic amine and an organic nitrogen compound that occurs to various degrees in many foods such as cherries to about 0.17-13.46 ng/g, bananas and grapes, rice and cereals, herbs, olive oil, wine, beer, etc.. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity(a). the hormone, as a neurotransmitter is involved in regulating physiological function in the gut and immune response to foreign pathogens.
The role of histamine H1 and H4 receptors in allergic inflammation
In the study to the effect of histamine in allergic inflammatory conditions, showed that histamine indeed has roles in inflammation and immune function modulation in such diseases. In particular, the discovery of a fourth histamine receptor (H4) and its expression on numerous immune and inflammatory cells has prompted a re-evaluation of the actions of histamine, suggesting a new potential for H4-receptor antagonists and a possible synergy between H1 and H4-receptor antagonists in targeting various inflammatory conditions(28).
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Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/17490952
(28) http://www.ncbi.nlm.nih.gov/pubmed/18172439
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2012-11-14 07:02:36
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