The role of histamine H4 receptor in immune and inflammatory disorders
Home of Kyle J. Norton for The Better of Living & Living Health (Hormone)Histamine, found within granules of basophils and mast cells (>90% of body stores) is a biogenic amine and an organic nitrogen compound that occurs to various degrees in many foods such as cherries to about 0.17-13.46 ng/g, bananas and grapes, rice and cereals, herbs, olive oil, wine, beer, etc.. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity(a). the hormone, as a neurotransmitter is involved in regulating physiological function in the gut and immune response to foreign pathogens.
The role of histamine H4 receptor in immune and inflammatory disorders
In the study the efficacy of a number of H4 receptor ligands has been evaluated in in vivo and in vitro animal models of disease and in human biological samples, showed that the available data strongly point to the H4 receptor as a novel target for the pharmacological modulation of histamine-transferred immune signals and offer an optimistic perspective for the therapeutic exploitation of this promising new drug target in inflammatory disorders(27).
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Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/17490952
(27) http://www.ncbi.nlm.nih.gov/pubmed/19309354
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2012-11-13 18:40:19
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