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Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer’s disease

Monday, January 21, 2013 5:41
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Home of Kyle J. Norton for The Better of Living & Living Health Thyroid hormone (triiodothyronine (T3) and thyroxine (T4)), produced by the thyroid gland, plays an important role in regulation of metabolism, including directly boosts energy metabolism and triggers rapid protein synthesis and regulates mitochondrial gene transcription, etc. Iodine is necessary for the production of T3 and T4, deficiency of Iodine can lead to enlarge thyroid grand and goitre.
Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer’s disease
There is an association between thyroid hormones in the central nervous system and Alzheimer’s disease (AD). In the study to determine thyroid hormone levels in serum and cerebrospinal fluid (CSF) in a well-defined homogeneous mono-center population, showed that  The CSF level of total T4 was decreased in patients with AD and other dementias compared to SMCI (both P=0.01) and healthy controls (both P=0.001), whereas CSF levels of TSH and total T3 were unchanged. In the total study population, CSF total T4 level correlated positively with MMSE score (r=0.26, P<0.05) and negatively with CSF total-tau (T-Tau) level (r=-0.23, P<0.05). Patients with AD as well as other dementias had signs of mild brain hypothyroidism, which could only to a small extent be detected in serum values(34).
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Sources 
(34) http://www.ncbi.nlm.nih.gov/pubmed/23159010   http://medicaladvisorjournals.blogspot.com



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