Thyroid hormone and Delayed development
Home of Kyle J. Norton for The Better of Living & Living Health Thyroid hormone (triiodothyronine (T3) and thyroxine (T4)), produced by the thyroid gland, plays an important role in regulation of metabolism, including directly boosts energy metabolism and triggers rapid protein synthesis and regulates mitochondrial gene transcription, etc. Iodine is necessary for the production of T3 and T4, deficiency of Iodine can lead to enlarge thyroid grand and goitre.
Thyroid hormone and Delayed development
In the study to investigate the phenotype of TTR(Transthyretin (TTR) is a TH distributor protein in the circulatory system and is the only TH distributor protein synthesised in the central nervous system) null mice during development by The University of Melbourne, showed that TTR null mice also displayed a delayed suckling-to-weaning transition, decreased muscle mass, delayed growth and retarded longitudinal bone growth. In addition, ileums from postnatal day 0 (P0) TTR null mice displayed disordered architecture and contained fewer goblet cells than wild type. Protein concentrations in cerebrospinal fluid from P0 and P14 TTR null mice were higher than in age-matched wild type mice(8).
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Sources
(8) http://www.ncbi.nlm.nih.gov/pubmed/23092911 http://medicaladvisorjournals.blogspot.com
2013-01-08 05:35:19
Source: http://medicaladvisorjournals.blogspot.com/2013/01/thyroid-hormone-and-delayed-development.html
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