Hormone Catecholamines – Dopamine and the inhibition of prolactin production
Home of Kyle J. Norton for The Better of Living & Living Health Hormone Catecholamines, derived from the amino acid tyrosine, produced by the adrenal glands, which are found on top of the kidneys. are epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. The hormone are released into the blood during times of physical or emotional stress.
Dopamine and the inhibition of prolactin production
Transcription of the prolactin gene is dynamically controlled by positive and negative hormone signals that target the regulatory promoter region. According to the study by University of Toronto, dopamine D2 receptor activation and inhibition of MAPK (ERK1/2) signaling lead to rapid deacetylation of histones at the genomic prolactin promoter. Recruitment of specific HDAC/ corepressor complexes may be an important mechanism for repression of target gene transcription by Gi/o-coupled receptors(11).
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(11) http://www.ncbi.nlm.nih.gov/pubmed/15731170 http://medicaladvisorjournals.blogspot.com
2013-03-16 04:48:58
Source: http://medicaladvisorjournals.blogspot.com/2013/03/hormone-catecholamines-dopamine-and_16.html
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