Hormone Leukotriene and local effects
Home of Kyle J. Norton for The Better of Living & Living Health According to the study of Prostaglandins and leukotrienes as inflammatory mediators by John A Salmon and Gerald A Higgs(a), Leukotrienes is produced in leukocytes as a result of oxidative metabolism of arachidonic acid by the enzyme arachidonate 5-lipoxygenase, belonging to the family of eicosanoid inflammatory mediators(a). Its production is usually accompanied by the production of histamine and prostaglandins.
Leukotriene and local effectsIn the study to assess the local effects of intracutaneous injections into humans of 1-3 nmol of five products of arachidonic acid metabolism, leukotrienes (LT) C4, D4, E4, and B4 from the 5-lipoxygenase pathways and prostaglandin (PG) D2 from the cyclooxygenase pathway, clinically and histologically, showed that The dermal vascular sites affected by LTD4 and PGD2 included capillaries, superficial and deep venules, and arterioles. LTB4 elicited a transient wheal and flare, followed in 3-4 hr by induration that was characterized by a dermal infiltrate comprised predominantly of neutrophils. The combination of LTB4 and PGD2 elicited tenderness and increased induration associated with a more intense neutrophil infiltration(7).
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Sources
(a) http://bmb.oxfordjournals.org/content/43/2/285
(7) http://www.ncbi.nlm.nih.gov/pubmed/6296237 http://medicaladvisorjournals.blogspot.com
2013-04-08 04:34:00
Source: http://medicaladvisorjournals.blogspot.com/2013/04/hormone-leukotriene-and-local-effects.html
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