The functions of The Hormone leukotrienes
Home of Kyle J. Norton for The Better of Living & Living Health According to the study of Prostaglandins and leukotrienes as inflammatory mediators by John A Salmon and Gerald A Higgs(a), Leukotrienes is produced in leukocytes as a result of oxidative metabolism of arachidonic acid by the enzyme arachidonate 5-lipoxygenase, belonging to the family of eicosanoid inflammatory mediators(a). Its production is usually accompanied by the production of histamine and prostaglandins.
The functions of The leukotrienesLeukotrienes (LTs) are metabolites of arachidonic acid formed by a 5-lipoxygenase and generated during immunological challenge or by reactions which involve changes in calcium levels. According to the study by the, Leukotriene B4 (LTB4), a dihydroxy metabolite, has been shown to exert marked chemotactic effect in many different animal species. LTB4 probably plays a role in inflammatory responses, and has been detected in several pathologic conditions. Reaction of LTA4, another lipoxygenase metabolite of arachidonic acid, with glutathione yields peptidolipid leukotrienes, LTC4, LTD4, and LTE4; these are components of slow reacting substance (SRS and SRS-A). The peptidolipid leukotrienes are potent bronchoconstrictors and enhance mucus production in the lungs. Furthermore, they constrict coronary arteries and have a negative inotropic effect. They probably play an important role in asthma and anaphylaxis. LTB4 and the peptidolipid leukotrienes may be important in several other organs, too, e.g., the skin and the eye. They may exert effects on a variety of smooth muscles and have neuronal and immunological effects(8).
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(a) http://bmb.oxfordjournals.org/content/43/2/285
(8) http://www.ncbi.nlm.nih.gov/pubmed/6096644 http://medicaladvisorjournals.blogspot.com
2013-04-09 04:18:50
Source: http://medicaladvisorjournals.blogspot.com/2013/04/the-functions-of-hormone-leukotrienes.html
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