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A team of UCLA researchers said they have figured out why ovarian cancer comes back after treatment with the chemotherapy drug carboplatin.
The researchers discovered that some of the tumor cells that don’t produce the protein CA125, have a strong ability to repair their DNA and resist programmed cell death. This allows the cells to dodge the effects of the drug and live long enough to engineer a relapse of the original tumor.
According to Deanna Janzen, the study’s lead author and a senior scientist in the G.O. Discovery Lab at UCLA, the ability of these cells to resist carboplatin therapy, along with their regenerative ability, is what makes them so dangerous.