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Genetic data now suggests that Crohn’s disease and ulcerative colitis is a continuum or progression of disorders influenced by the location of inflammation in the gut.
About 1.4 million Americans have Crohn’s disease or ulcerative colitis. Diagnosis could be oversimplified though. This according to genetic data that shows the diseases are a complex continuum of disorders influenced by the site of the inflammation involved.
The location of disease in Crohn’s has always been considered important, but there has been a new observation that large bowel Crohn’s disease is halfway between ulcerative colitis and small bowel Crohn’s on the genetic spectrum, which suggests the vital aspects of the disease biology are linked to location.