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Consuming eggs and other high-cholesterol foods does not increase the risk of heart attack. Furthermore, there is no association between those with the APOE4 phenotype and a high-cholesterol diet.
Dietary cholesterol only affects serum cholesterol. A minor and limited research has found a link between dietary cholesterol and an increase in cardiovascular disease. Worldwide, there are minimal limitations on consuming high-cholesterol foods, but in those with APOE4, which largely impacts cholesterol metabolism, dietary cholesterol can have a greater effect. In Finland particularly, APOE4 is quite common with one-third of the population being a carrier of the gene variant, and so it’s important to know if dietary cholesterol affects this population’s risk of heart attack.