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Researchers Produce Tissue-Engineered Human Colon from Postnatal Donor Colon
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Researchers have for the first time grown tissue-engineered human large intestine. The human tissue-engineered colon includes all of the required specialized cell types that are found in human large intestine. The research team grew the tissue-engineered large intestine from specific groups of cells, called organoid units that were derived from intestinal tissue normally discarded after surgery. The organoid units grew on a biodegradable scaffold. After 4 weeks, the human tissue-engineered colon contained the differentiated cell types required in the functioning colon, and included other key components including smooth muscle, ganglion cells, and components of the stem cell niche. Identification of a human-specific protein confirmed that the tissue-engineered large intestine grew from human cells. This proof-of-concept experiment is an important step in transitioning tissue-engineered colon to human therapy.
See more and subscribe to NextBigFuture at 2012-11-10 11:22:02 Source: http://nextbigfuture.com/2012/11/researchers-produce-tissue-engineered.html
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