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Gene therapy shows promise in eradicating some blood cancers

Friday, December 14, 2012 9:41
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From NextBigFuture.com

Out of 10 patients, only two patients have not gotten better on the T cell therapy, even though all had stopped responding to conventional treatments. Four patients have had a complete response – their leukemia was eradicated – with the longest so far lasting 28 months. In four other patients, leukemia diminished dramatically.

This is the same treatment that was described in a Nextbigfuture article yesterday. Novartis has the rights to this and is developing it.

“We believe we know why the two patients didn't respond,” said Penn physician David L. Porter, a cancer and blood specialist. “If we're right, it's something we can fix.”

The therapy, culminating 20 years of research, involves genetically engineering T cells – the immune system's big guns – to attack B cells, the blood component that turns malignant in chronic lymphocytic leukemia and acute lymphoblastic leukemia.

Interfering with the immune system, however, is dicey. From the start, it was clear the designer T cells had side effects that caused flulike symptoms.

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