Winning Is Everywhere In the Brain

The study published in the Oct. 6 issue of the journal Neuron shows that when participants play games, such as rock-paper-scissors, almost the entire brain is engaged, not just the reward centers of the brain, which have been assigned the central role for shaping adaptive human behavior.

"Our brain functions to maximize the chance of survival and reproduction, so reward should be important for all cognitive functions, and thus most brain regions," said Timothy Vickery, postdoctoral fellow in the Department of Psychology and lead author of the study.

Textbooks teach that sensations of reward and punishment are centered in a region at the center of the brain called the basal ganglia, which contains a network of cells distributing dopamine, a neurotransmitter that reaches into the prefrontal cortex and other areas of the brain. The theory has been confirmed by previous functional magnetic imaging (fMRI) scans that show high levels of activity in the dopamine network when subjects are presented by desirable or frightening stimuli.

Vickery — along with Yale colleagues Marvin Chun, professor of psychology and neurobiology, and senior author Daeyeol Lee, professor of neurobiology, psychology and researcher for the Kavli Institute of Neuroscience — wanted to know if the textbooks were leaving out the role of other brain areas. They used a technique called multi-voxel pattern analysis to analyze fMRI data. Instead of comparing the overall signal strength corresponding to reward and punishment within each region of the brain, the new analysis looked for patterns within patches of brain activity. Just as a computer vision algorithm is trained to "recognize" objects from an image pattern, this technique involves training the computer to "recognize" reactions to wins and losses from brain activity patterns.

They found that wins and losses in games were recognizable from almost all areas of the brain.

"We aren't saying that the dopamine network is not the core system of reward processing in the brain," Vickery said. "Our novel point is that this information makes it way throughout the entire brain in a much more far-reaching manner than previously thought."