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Japanese Condiment Fights Highly Lethal Pancreatic Cancer
By Sayer Ji – greenmedinfo
A promising new study published in Evidence-Based Complementary and Alternative Medicine titled, “Effect of Wasabi Component 6-(Methylsulfinyl)hexyl Isothiocyanate and Derivatives on Human Pancreatic Cancer Cells,” reveals the potent Japanese horseradish concoction known as wasabi may help fight highly lethal pancreatic cancer by striking to the very root cause of cancer malignancy and its resistance to conventional treatment.
A team of Taiwanese researchers studied the effects of a naturally occurring wasabi isolate, compound 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC), and two of its synthetic derivatives (I7447 and I7557, respectively), on human pancreatic cancer cells. They used two pancreatic cell lines known as PANC-1 and BxPC-3, respectively, and measured their responses to the wasabi derived compounds using the following techniques:
- MTT assay for cell viability (i.e. measuring the number of viable cells present)
- Liu's stain for morphological observation (i.e. changes in cell shape)
- DNA histogram for cell cycle.
- Aldehyde dehydrogenase (ALDH) activity was used as a marker for cancer stem cells (CSC)
- Western blotting was performed for the expression of proteins related to CSC signaling.
Source: http://www.riseearth.com/2014/04/japanese-condiment-fights-highly-lethal.html
