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My research on myalgic encephalomyelitis.
I wanted to get this out there now. Big changes are coming… I have gotten much sicker after the cold weather started, and getting another virus infection. I am moving out of my home soon, and I don’t know how this is possible without significant muscle exertion, which will makes the disease much worse. So massive uncertainty clouds my immediate future.
I still think I will get better after the weather warms up, but right now there is more snow and severe cold in the forecast, and I don’t know when this will happen.
Most of the links are from Facebook. I apologize to those who cannot access it. There is a way to synchronize Facebook posts to this blog, but I am too sick to do it now.
Type I interferons and interferon-gamma in ME. https://www.facebook.com/photo.php?fbid=1568940223351599&set=a.1378980989014191.1073741827.100007069086339&type=1&permPage=1
Immunosuppression causes persistence of enteroviral infections in ME, is the foundation of exertion intolerance, and can be reversed by Type I interferon blockers. https://www.facebook.com/photo.php?fbid=1563980117180943&set=a.1378980989014191.1073741827.100007069086339&type=1&permPage=1
Enterovirus infections of the central nervous system. https://www.facebook.com/rob.soltysik/posts/1563235883922033
Enterovirus infection of the gastrocnemius muscle, IDO, and peroxynitrite. https://www.facebook.com/photo.php?fbid=1560108380901450&set=a.1378980989014191.1073741827.100007069086339&type=1&permPage=1
Serotonin, IDO, and reduced tryptophan catabolism in ME. https://www.facebook.com/photo.php?fbid=1559486410963647&set=a.1378980989014191.1073741827.100007069086339&type=1&permPage=1
Picolinic acid deficiency in ME and the kynurenine pathway. https://www.facebook.com/rob.soltysik/posts/1555924694653152
TGF-beta is released from muscles 24 hours after exercise, and reduces levels of interferon-gamma. https://www.facebook.com/rob.soltysik/posts/1554380474807574
TGF-beta reduces NK cell cytolytic activity and MHC I and II expression. https://www.facebook.com/photo.php?fbid=1553685861543702&set=a.1378980989014191.1073741827.100007069086339&type=1&permPage=1
Kynurenine as a possible treatment for ME. https://www.facebook.com/rob.soltysik/posts/1552493944996227
Dysregulation of the STAT-1 protein in ME. https://www.facebook.com/rob.soltysik/posts/1550320275213594
Activin in ME, generated from muscle activity. https://www.facebook.com/photo.php?fbid=1549061655339456&set=a.1378980989014191.1073741827.100007069086339&type=1&theater
Caffeine inhibits tryptophan hydroxylase, which is upgraded after exercise. https://www.facebook.com/rob.soltysik/posts/1548335098745445?
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Swimming exercise increases serotonin levels, and decreases corticosterone, interferon-gamma, TNF-alpha, and IDO levels. https://www.facebook.com/rob.soltysik/posts/1548663458712609
The TGF-beta autocrine loop in ME. https://www.facebook.com/photo.php?fbid=1545550062357282&set=a.1378980989014191.1073741827.100007069086339&type=1&permPage=1
Psychedelics and the desensitization of the 5-HT2A receptor. https://www.facebook.com/rob.soltysik/posts/1545566525688969
Exercise-induced reduction of interferon-gamma levels is the cause of post-exertional immune exhaustion in ME. https://www.facebook.com/photo.php?fbid=1545094079069547&set=a.1378980989014191.1073741827.100007069086339&type=1&permPage=1
Omega-3 fatty acids protect against TGF-beta-induced heart damage. https://www.facebook.com/photo.php?fbid=1542221296023492&set=a.1378980989014191.1073741827.100007069086339&type=1&permPage=1
GABA-B positive allosteric modulators are an effective treatment for ME, but are not yet approved by the FDA. https://www.facebook.com/photo.php?fbid=1543716249207330&set=a.1378980989014191.1073741827.100007069086339&type=1&permPage=1
List of TGF-beta inhibitors. I have determined that only those medications that use the Smad pathway are effective for ME. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156642/table/T1/
Brief moderate stretching is effective for reducing post-exertional symptoms after exercise. https://www.facebook.com/rob.soltysik/posts/1538396193072669
Moderate acute exercise increases TGF-beta, alpha-amylase, and IgA 24 hours after exercise. https://www.facebook.com/photo.php?fbid=1537561009822854&set=a.1378980989014191.1073741827.100007069086339&type=1
Noise increases tryptophan hydroxylase levels, which is a factor in noise hypersensitivity in ME. https://www.facebook.com/rob.soltysik/posts/1535163920062563
Brown fat, a key player in ME. https://www.facebook.com/photo.php?fbid=1534909633421325&set=a.1378980989014191.1073741827.100007069086339&type=1&permPage=1
Follistatin increases muscle mass after exercise, reduces TGF-beta levels via the Smad pathway, and is a myostatin inhibitor. The muscle repair process recruits interferon-gamma from tissues, and is the cause of exertion intolerance. https://www.facebook.com/rob.soltysik/posts/1534220460156909
Interferon-gamma deficiency in “chronic fatigue syndrome” – 1990, after the name change from ME. https://www.facebook.com/photo.php?fbid=1534083273503961&set=a.1378980989014191.1073741827.100007069086339&type=1
Ionizing radiation exposure is part of the ME disease process, by its generation of peroxynitrite (ONOO-) via radiolysis. https://www.facebook.com/photo.php?fbid=1527337944178494&set=a.1378980989014191.1073741827.100007069086339&type=1&permPage=1
Destruction of groups 1 and 3 innate lymphoid cells and the resultant distortion of commensal bacteria is a fundamental aspect of the ME disease process. https://www.facebook.com/photo.php?fbid=1526481204264168&set=a.1378980989014191.1073741827.100007069086339&type=1
Psilocybin reduces the activity of the default mode network. The inability to deactivate the DMN is behind the overwhelming neurological and cognitive symptoms in severe ME. https://www.facebook.com/rob.soltysik/posts/1524990264413262
Actimmune (interferon-gamma) is an effective treatment for ME. It does not reduce Type I interferon levels, though, which is necessary for a cure. https://www.facebook.com/photo.php?fbid=1519863351592620&set=a.1378980989014191.1073741827.100007069086339&type=1
Psilocybin reduces DMN activity by activating the 5-HT2A receptors. The receptors are typically desensitized in ME due to excessive serotonin production. https://www.facebook.com/rob.soltysik/posts/1503265213252434
A high-fat diet restores interleukin-22, and also restores the balance of microbiota in the gut. https://www.facebook.com/photo.php?fbid=1472133589698930&set=a.1378980989014191.1073741827.100007069086339&type=1
Limbic kindling vs. central sensitization in ME. My response to Leonard Jason’s research. http://optimalprediction.com/wp/limbic-kindling-vs-central-sensitization-in-me/
Ketogenic diet for M.E.: Can it really be this simple? http://optimalprediction.com/wp/ketogenic-diet-for-m-e-can-it-really-be-this-simple/
How ME and radiation sickness has altered my mechanism of thinking. http://optimalprediction.com/wp/how-me-and-radiation-sickness-has-altered-my-mechanism-of-thinking/
Origin of M.E. disease process in the immune system. I have found since this, that an enteroviral infection of certain immunoprivileged areas of the brain does the same thing. Any viral, radiotoxic, or other toxic infestation of these brain areas will cause this. It is now known that the upgrade of Type I interferons is behind the dysregulation of the JAK/STAT pathway. http://optimalprediction.com/wp/origin-of-m-e-disease-process-in-the-immune-system/
Read more here http://optimalprediction.com/wp/
Source: http://optimalprediction.com/wp/my-research-on-myalgic-encephalomyelitis/
