Systemic sclerosis – scleroderma – is an independent risk factor for atherosclerosis, which is hardening of the arteries. The findings come from researchers in Hong Kong who uncovered that scleroderma can contribute to atherosclerosis. Among the known risk factors for atherosclerosis are age and hypertension. Scleroderma is a connective tissue disorder in which the tissue of the skin becomes hardened due to an increase in collagen. It is estimated that 49,000 Americans suffer from scleroderma. Research has revealed that scleroderma patients are often at a higher risk for coronary artery disease, the risk factors for which has long been unknown.