Pyridoxine (vitamin B6) toxicity – Chronic demyelinating polyneuropathy and B6 hypervitaminosis

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Home of Kyle J. Norton for The Better of Living & Living Health The vitamin B-complex are essential water-soluble vitamins, including vitamin B1(thiamine), vitamin B2 (riboflavin ), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), biotin, folic acid and vitamin B12 (cobalamins).
Vitamin B6 is a water-soluble vitamin and a member of vitamin B complex, found abundantly in cereal grains, legumes, vegetable, milk, cheese, eggs, fish, liver, meat, . It plays an important role in neurotransmitter function with secondary cerebral and cerebellar hypoplasia. and converts foods (fats, ketone bodies, carbohydrates, and proteins) to energy.
Chronic demyelinating polyneuropathy and B6 hypervitaminosis
There is a report of a 62-year-old patient who presented with a several month history of a peripheral sensory neuropathy with ataxia that was attributed to a chronic immune demyelinating polyneuropathy but was resistant to corticosteroid therapy. Diagnostic workup finally showed a high serum level of pyridoxin related to a chronic intake of oral vitamin medication for several years. We discuss the link between the clinical and electrophysiological manifestations of the chronic polyneuropathy, based on similar reported observations in the literature. This observation highlights the possibility of important long-term deleterious effects of vitamin oral supplementations, particularly pyridoxin(2).

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