Hormone Leukotrienes in rheumatoid arthritis
Home of Kyle J. Norton for The Better of Living & Living Health According to the study of Prostaglandins and leukotrienes as inflammatory mediators by John A Salmon and Gerald A Higgs(a), Leukotrienes is produced in leukocytes as a result of oxidative metabolism of arachidonic acid by the enzyme arachidonate 5-lipoxygenase, belonging to the family of eicosanoid inflammatory mediators(a). Its production is usually accompanied by the production of histamine and prostaglandins.
Leukotrienes in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disorder of joints for which there is no strict cure. According to the study by the Tehran University of Medical Sciences, Leukotrienes (often leukotriene B4) as potent chemotactic agents can provoke most signs and symptoms in rheumatoid arthritis by initiating, coordinating, sustaining, and amplifying the inflammatory response, through recruitment of leukocytes. A number of studies have reported that pharmacological modulation in this field can significantly attenuate clinical manifestations associated with different inflammatory pathologies(10).
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Sources
(a) http://bmb.oxfordjournals.org/content/43/2/285
(10) http://www.ncbi.nlm.nih.gov/pubmed/23529572 http://medicaladvisorjournals.blogspot.com
2013-04-11 04:34:09
Source: http://medicaladvisorjournals.blogspot.com/2013/04/hormone-leukotrienes-in-rheumatoid.html
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