Benedict XVI is expected to speak mostly about Jesus – he has just written the second of two volumes on Christ's life, "Jesus of Nazareth", due to be published on Thursday.
He will appear on a religious affairs programme called "In his image", which will be aired on Good Friday – April 22.
It will be broadcast at 2.10pm in Italy (1.10pm GMT), the time recognised by the Catholic Church as the moment that Christ died on the cross after being crucified.
A special website will be launched on Sunday to which Catholics can send suggested questions, from which just three will be chosen and put to the German-born pontiff, who was elected in 2005.
The programme, on Italy's state broadcaster, RAI, will be pre-recorded at the Vatican a few days before, either in the Pope's study or his personal chapel.
