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Quantitatively probing propensity for structural transitions in engineered virus nanoparticles by single-molecule mechanical analysis
Friday, March 6, 2015 2:42
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Where size matters
Nanoscale , 2015, Advance Article
DOI: 10.1039/C4NR07046A, Paper
Milagros Castellanos, Pablo J. P. Carrillo, Mauricio G. Mateu
In a virus particle, the free energy barrier of an inactivating structural transition is linearly related to mechanical stiffness. Elasticity measurements may be applied for probing conformational dynamics of virus-based nanoparticles.
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