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19 new transcription factors break bottleneck that limited synthetic biology complexity

Sunday, August 5, 2012 1:50

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From NextBigFuture.com

For about a dozen years, synthetic biologists have been working on ways to design genetic circuits to perform novel functions such as manufacturing new drugs, producing fuel or even programming the suicide of cancer cells.

Achieving these complex functions requires controlling many genetic and cellular components, including not only genes but also the regulatory proteins that turn them on and off. In a living cell, proteins called transcription factors often regulate that process.

So far, most researchers have designed their synthetic circuits using transcription factors found in bacteria. However, these don’t always translate well to nonbacterial cells and can be a challenge to scale, making it harder to create complex circuits, says Timothy Lu, assistant professor of electrical engineering and computer science and a member of MIT’s Research Laboratory of Electronics.

Lu and his colleagues at Boston University (BU), Harvard Medical School and Massachusetts General Hospital (MGH) have now come up with a new method to design transcription factors for nonbacterial cells (in this case, yeast cells). Their initial library of 19 new transcription factors should help overcome the existing bottleneck that has limited synthetic biology applications, Lu says.